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Oral metronidazole has long been reported to potenti-ate the anticoagulant outcome of coumarin and warfarin leading to a prolongation of prothrombin time. The effect of topical metronida-zole on prothrombin time is just not recognised.
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Metronidazole has proven evidence of mutagenic activity in a number of in vitro bacterial assay units. Furthermore, a dose-connected rise in the frequency of micronuclei was observed in mice right after jnetoto intraperitoneal injections. An increase in chromosomal aberrations in peripheral blood lymphocytes was reported in patients with Crohn’s disease who were being addressed with 200 to 1200 mg/working day of metronidazole for 1 to 24 months.
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Other outcomes that have been reported in association with the use of topical jnetoto (dermal) formulations of metronidazole incorporate skin irritation, transient skin erythema, and delicate pores and skin dryness and burning. None of these adverse occasions exceeded an ‑incidence of 2% of people
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